We greatly appreciate your detailed and constructive comments. In our study, we defined a "low dose" as less than 5 mL [1]. However, we did not propose a precise amount of ethanol according to the nodule volume or the cystic nature of the thyroid nodule. This might be a limitation of our retrospective study. Further research is necessary. Although the exact dosage of ethanol has not been established yet, the concept of single-session low-dose ethanol ablation (EA) might be important in terms of the basic principle for drug injection, which is to obtain the maximum effect with the minimum amount. Using a small amount of ethanol has the advantages of being easy to handle during the procedure and minimizing the risk of procedure-related complications, including ethanol leakage and patient discomfort.