Journal of Korean Society of Ultrasound in Medicine 2007;26(1): 13-19.
Usefulness of High-Frequency Compound Spatial Sonography in the Assessment of Hepatitis B Virus Related Chronic Liver Disease.
Hyung Soo Kim, Sang Hoon Cha, Hwan Hoon Chung, Ki Yeol Lee, Baek Hyun Kim, Kyung Ah Kim, Yoon Hwan Kim, Cheol Min Park, Eung Seok Lee, Kwan Soo Byun
1Department of Radiology, Wonkwang University College of Medicine, Korea.
2Department of Radiology, Korea University College of Medicine, Korea.
3Department of Pathology, Korea University College of Medicine, Korea.
4Department of Internal Medicine, Korea University College of Medicine, Korea.
  Published online: March 1, 2007.
PURPOSE: To evaluate the liver parenchyma according to the echo patterns of CSS (compound spatial sonography), and to correlate them with the extent of hepatic fibrosis and the serum aminotransferase level. MATERIALS AND METHODS: The CSS images were classified into the following three echo patterns: type I, a normallooking echo; type II, hyperechoic or hypoechoic nodules scattered in a normal-looking echo; type III, a severely heterogeneous echogenic or hypoechoic honeycomb-like echo. The CSS findings were correlated with the histopathology findings in 63 patients with HBV. The serum aminotransferase levels and the occurrence of acute exacerbation in 168 patients with HBV, with and without a progressed parenchymal echo pattern, and who were followed up more than 1-year period, were compared. The interobserver agreement between the two radiologists for assessing the parenchymal echo pattern was scored. RESULTS: The correlation between the CSS pattern and hepatic fibrosis was statistically significant (correlation coefficient = 0.58, p < 0.05). The baseline serum aminotransferase level was not significantly different between the patients with and without a progressed parenchymal echo pattern. However, the rate of acute exacerbation was higher in patients with a progressed parenchymal echo pattern (p < 0.05). The interobserver agreement was good (k statistic = 0.63, 0.78). CONCLUSION: The liver parenchymal pattern based on the 5-12 MHz CSS is a useful and objective tool for diagnosing and monitoring HBV related chronic liver disease.
Keywords: Liver, fibrosis; Liver, US; Ultrasound (US), utilization; Hepatitis
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