Journal of Korean Society of Medical Ultrasound 2000;19(4): 311-318.
Contrast-Enhanced Color Doppler US in Breast Cancer: Tumoral Vascularity Correlated with Angiogenesis.
Eun A Kim, Kwon Ha Yoon, Ki Jung Yun, Kwang Man Lee, Ki Han Park, Seon Kwan Juhng, Jong Jin Won
1Department of Radiology, Wonkwang University School of Medicine.
2Department of Pathology, Wonkwang University School of Medicine.
3Department of General Surgery, Wonkwang University School of Medicine.
  Published online: January 1, 2001.
PURPOSE: To evaluate the effects of contrast-enhanced color Doppler ultrasonography (CDUS) on the depiction of vascularity and flow pattern in breast cancer and to determine the relationship between tumoral vascularity and angiogenesis. MATERIALS AND METHODS: Twenty-one patients with breast cancer were prospectively evaluated with CDUS before and after injection of the contrast agent (SH U 508A, 2.5g, 300mg/ml). The tumoral vascularity was expressed as percentage of color Doppler area, which was measured quantitatively by a computerized program (Ultrasonic Imaging Tool; Soongsil University, Seoul, Korea). The flow pattern (four-patterns; spotty, linear, branching, marginal) of the vascularity was analyzed. After surgery, tumor angiogenesis was assessed by microvessel den-sity. The relationship between the vascularity on CDUS and microvessel density was statistically analyzed. RESULTS: At unenhanced CDUS, tumoral flow signals were detected in 12 lesions (48%); at contrast-enhanced CDUS, 18 lesions (86%). All These 18 lesions showed increased signals, compared with those at unenhanced CDUS. The percentage color Doppler area was 1.86 +/- 0.48% at unenhanced CDUS and 5.23 +/- 1.18% at con-trast- enhanced CDUS. The flow patterns before contrast injection were spotty pattern in 11 tumors and linear pattern in one; after contrast injection, spotty in 8, linear in 4, branching in 5, and marginal in one. The tumoral vascularity at contrast-enhanced CDUS showed no significant correlation with microvessel density. CONCLUSION: Contrast-enhanced CDUS seems to be a valuable tool in the depiction of vascularity and characteri-zation of flow pattern in breast cancer. However, tumoral vascularity on CDUS may not reflect tumoral angio-genesis.
Keywords: Breast, US; Breast neoplasms; Breast neoplasms, US
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